Lucília Saraiva Selected Research

tryptophanol

1/2021	Potency and Selectivity Optimization of Tryptophanol-Derived Oxazoloisoindolinones: Novel p53 Activators in Human Colorectal Cancer.
1/2020	SLMP53-1 Inhibits Tumor Cell Growth through Regulation of Glucose Metabolism and Angiogenesis in a P53-Dependent Manner.
8/2019	SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma.
10/2018	Improving anticancer activity towards colon cancer cells with a new p53-activating agent.
5/2015	A tryptophanol-derived oxazolopiperidone lactam is cytotoxic against tumors via inhibition of p53 interaction with murine double minute proteins.

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Lucília Saraiva Research Topics

Disease

26	Neoplasms (Cancer) 01/2022 - 11/2009
5	Colonic Neoplasms (Colon Cancer) 05/2019 - 01/2017
3	Carcinogenesis 01/2022 - 01/2019
2	Inflammation (Inflammations) 01/2022 - 09/2014
2	Melanoma (Melanoma, Malignant) 08/2021 - 04/2021
2	Colorectal Neoplasms (Colorectal Cancer) 01/2021 - 01/2021
2	Parkinson Disease (Parkinson's Disease) 01/2019 - 04/2015
2	Breast Neoplasms (Breast Cancer) 01/2019 - 12/2018
1	Sarcoma (Soft Tissue Sarcoma) 01/2022
1	Triple Negative Breast Neoplasms 08/2021
1	Ovarian Neoplasms (Ovarian Cancer) 01/2021
1	Bacterial Infections (Bacterial Infection) 10/2019
1	Hepatocellular Carcinoma (Hepatoma) 08/2019
1	Neuroblastoma 01/2019
1	Necrosis 11/2015
1	Gliosis 09/2014
1	Disease Progression 03/2012

Drug/Important Bio-Agent (IBA)

13	Proteins (Proteins, Gene)FDA Link 01/2022 - 03/2012
5	tryptophanolIBA 01/2021 - 05/2015
3	SLMP53-2IBA 01/2022 - 08/2019
3	Lactic Acid (Lactate)FDA LinkGeneric 04/2021 - 01/2018
2	Protein Isoforms (Isoforms)IBA 08/2021 - 12/2020
2	Poly(ADP-ribose) Polymerase InhibitorsIBA 07/2021 - 01/2021
2	Antineoplastic Agents (Antineoplastics)IBA 01/2021 - 08/2019
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2021 - 11/2015
2	Cisplatin (Platino)FDA LinkGeneric 01/2021 - 01/2019
2	Pharmaceutical PreparationsIBA 12/2020 - 01/2018
2	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 01/2018
2	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 01/2020 - 01/2019
2	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2019 - 10/2018
2	Caspase 7IBA 12/2018 - 04/2014
2	LactamsIBA 10/2018 - 05/2015
2	Tumor Suppressor Protein p53IBA 01/2018 - 05/2015
2	Caspase 3 (Caspase-3)IBA 01/2018 - 04/2014
1	DNA (Deoxyribonucleic Acid)IBA 01/2022
1	frutalinIBA 08/2021
1	carbazoleIBA 03/2021
1	AlkaloidsIBA 03/2021
1	olaparibIBA 01/2021
1	Cadherins (E-Cadherin)IBA 01/2020
1	2- (4- hydroxy)- benzoyloxy- 11- hydroxy- 5,7,9(11),13- abietatetraen- 12- oneIBA 10/2019
1	AbietanesIBA 05/2019
1	Rosmarinic AcidIBA 05/2019
1	coleon UIBA 05/2019
1	xanthoneIBA 05/2019
1	AcetoneIBA 01/2019
1	Leucine (L-Leucine)FDA Link 01/2019
1	Phosphotransferases (Kinase)IBA 01/2019
1	Adenosine Triphosphate (ATP)IBA 01/2018
1	IsoenzymesIBA 01/2018
1	lysyl- arginyl- alanyl- lysyl- alanyl- lysyl- threonyl- threonyl- lysyl- lysyl- arginine (PKCS)IBA 01/2018
1	Protein Kinases (Protein Kinase)IBA 01/2018
1	Protein Kinase CIBA 01/2018
1	Phorbol EstersIBA 01/2018
1	Transcription Factors (Transcription Factor)IBA 01/2017
1	DIMP53-1IBA 01/2017
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 04/2015
1	pyrimidineIBA 09/2014
1	Uridine Triphosphate (UTP)IBA 09/2014
1	Uridine Diphosphate (UDP)IBA 09/2014
1	Uracil NucleotidesIBA 09/2014
1	purinoceptor P2Y6IBA 09/2014
1	FlavonoidsIBA 04/2014
1	gambogic acidIBA 04/2013
1	mangostinIBA 04/2013

Therapy/Procedure

16	Therapeutics 01/2022 - 11/2009
1	Chemoprevention 01/2020
1	Traditional Medicine (Folk Remedies) 10/2019
1	Drug Therapy (Chemotherapy) 10/2018